I read an eye-opening article a a couple months ago in Trail Runner magazine (good publication, by the way). It talked about the use (and overuse) of Ibuprofen in the running community, and the dire effects it can have. I had always thought it harmless and even 'healthy' to take Ibuprofen, with the logic that reduced inflammation will help the body both cope with and heal from the intense demands placed on it. The article suggests a few things based on research:
- there is no real evidence that NSAIDs (such as Ibuprofen) reduce muscle damage and soreness
- daily use of Ibuprofen increases the risk of gastrointestinal bleeding and interferes with the creation of collagen, making it harder for muscles, tissues and bones to heal properly (counterproductive even)
- Ibuprofen places additional stresses on the body, especially for long distance runners (e.g. ultrarunners) whose systems are already compromised due to dehydration, fatigue, and environmental stress (e.g. heat)
The article goes on to say that hyponatremia increases the risk of rhabdomyolsis (muscle breakdown that produces waste products that 'clog' the kidneys), which can lead to acute renal failure.
"Holy shit", I said, as I flashed back to the millions of times I've popped Ibuprofen to get me through long runs, and with complete disregard for dosage.
The effects are being seen at races (nausea, vomiting, swollen ankles, often misdiagnosed) and these racers are taking doses that would not be considered extraordinary. (One elite competitor that suffered acute kidney failure said that he had taken 1000 mg over a 9 hour period).
The maximum daily recommended dose of Ibuprofen is 1200 mg.
The athletes are not overdosing, per se, it's just that the ibuprofen, combined with intense exercise conditions, can do wacky things in your body.
The net-net is that Ibuprofen is not harmless, as I had always assumed, and that you need to use wisely. That means as-needed, right dosage, and definitely do not use it daily or for an extended period. Better yet, if the benefits are not profound, just skip it altogether.
*Ibuprofen is sold as Advil, Motrin, Nurofen, and others